6th World Workshop on Oral Health and Disease in AIDS
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Susceptibility Gene Type Analysis in Xinjiang Uygur Patients with HIV |
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Susceptibility Gene Type Analysis in Xinjiang Uygur Patients with HIV |
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| Z.-Q. LI, L.-J. ZHONG, J. NI, J. XU, and G. LI Department of Stomatology, the First Affiliated Hospital of Xinjiang Medical University, Urmuqi, China Objective: To discuss the clinical presentations and prognosis changes in Xinjiang Uygur patients with HIV whose CCR5-32,CCR2-64I and SDF1-3A genes have mutations . Methods: Buccal exfoliated cells were taken from 20 Xinjiang Uygur patients with HIV-infection and DNA extracted with Chelex-100 and analyzed for the CCR5, CCR2and SDF1 susceptibility genes with the methods of PCR, digestion and electrophoresis. The result was compared with their presentation and prognosis. Results: There was 1case CCR2-64I gene mutation and 1case SDF1-3'A gene mutation. Their clinical presentations were milder and prognosis better than the other patients. Conclusions: CCR2-64I or SDF1-3'A gene mutations can delay the disease course of Xinjiang Uygur patients with HIV and their clinical presentations are milder and their prognosis better than any other patients. It is a new idea for prevention and cure for Xinjiang patients with HIV. |
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