Inhibitory Role of Human Salivary Mucins within HIV Infection

Ronden Perwiradinata, Adiastuti Endah Parmadiati, Desiana Radithia

Oral Medicine, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia.



Objectives: HIV and the interaction with the infected host is an abundant field for research. The latest research is developed to examine the role of salivary mucins role in the inhibiton of HIV infection. This article aims to review the literature on the salivary mucins and the inhibiton of HIV infection.


Methods: The reliability and validity of salivary mucins when inhibiting HIV infection remains unclear. We review and synthesize the published studies that have examined salivary mucins inhibitory role within HIV. A literature review was performed in PMC databases from 2009 to 2019.


Results: There were 123 papers and 28 were selected according with inclusion and exclusion criteria. Salivary mucins have a potential role in inhibition activity within HIV infection.


Conclusions: Salivary mucins have an ability to inhibit HIV infection. Further research  is needed to determine the salivary mucin interaction with HIV.