Oral Manifestation of HIV: Can It Be an Indicator
of Disease Severity? (Systematic Literature Reviews)

Ratna Kumala Indrastiti, Indriasti I Wardhany, Anandina I Soegyanto 

Department of Oral Medicine, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia



Objective: To review the existing literature on the paradigm that the oral lesions could be an indicator or the disease progression with the objective of documenting the current status of research and highlighting its major findings.


Material and methods: Publications were identified through a careful search of available papers which focused on oral lesions as an indicator for HIV progression. A PubMed journal search for the years 2009-2019 looking for "oral lesion, oral manifestation, indicator, HIV and HIV-associated" was performed and analyzed. Various research methods were included within the study criteria including clinical study, clinical trial, comparative study, and randomised control trial.


Results: A total 33 studies were obtained and analysed, includes Cohort study, Cross- sectional study, Case control study, Clinical Trial, Retrospective observational analysis study, Prospective observational study, and Randomized Control Trial. The most  common oral lesions found in the studies were Non-Hodgkin Lymphoma (NHL), Kaposi's Sarcoma (KS) and Candidiasis. The early diagnosis and an accurate treatment plan were very important to indicate the HIV progression.


Conclusion: It iss very important for dentists to be able to recognise and diagnose the oral lesions associated with HIV and to understand their relationship to the progression of that disease.


Keywords: oral lesion, oral manifestations, HIV, HIV-associated